We provide research training in three areas where we have a critical mass of experienced faculty, exemplary Institution support, and superb resources for state of the art research, notably for proteomics. These areas are biotransformation, DNA damage & repair, and pathophysiology which share a unifying theme of oxidative stress. Training in the broad area of pathophysiology will emphasize injury to the CNS (brain and eye), GI tract, and asthma pathogenesis which meshes with our strong participation by physician-scientists in the Asthma Pathogenesis research core of our newly renewed NIEHS Center Grant. A unique feature of our proposed training is that research projects by several faculty in each area include assessments of the influences of aging and infection. An updated curriculum builds from an interdisciplinary common first year towards advanced courses in molecular toxicology, pathology, proteomics / bioinformatics, and intensive short courses on specialized topics that are taught by visiting scientists.